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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Activation of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the immunosuppression of mice infected with Angiostrongylus cantonensis

Fig. 6

Brain injury caused by A. cantonensis infection-induced lymphopenia and HPA axis activity. a Mice were infected with A. cantonensis first, followed by the albendazole treatment from 7 to 14 dpi. Images of the spleen and thymus of 21 dpi mice were shown. Naïve mice were used as control. b Percentages of splenic B cells, T cells, CD4+ T, and CD8+ T cells in infected mice (14, 16, 18, and 21 dpi) with albendazole treatment. Naïve mice were used as control. c C-fos mRNA levels in the hippocampus, PVN, pituitary gland, and adrenal glands. d CRH mRNA levels in the PVN. e TH mRNA levels in the adrenal glands. f Serum corticosterone levels in infected mice (14, 16, 18, and 21 dpi) and control mice. g Glucocorticoid receptor mRNA levels in the BM from infected mice and control mice. Each group contained four to six mice. One of two independent experiments with similar results is shown. Values were shown as mean ± SEM. A two-tailed t test was used for statistical analysis. *, results differed from the control group; *P < 0.05; ***P < 0.001

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