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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Activation of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the immunosuppression of mice infected with Angiostrongylus cantonensis

Fig. 7

RU486 treatment partially reversed cessation of B cell genesis in A. cantonensis-infected mice. Mice were infected with A. cantonensis first and treated with RU486 or sesame oil daily since 10 dpi until sacrificed. a, b Developing B cells in the BM were gated on B220+AA4.1+ cells first (upper panels) and further analyzed for IgM+CD19+ immature (IMM) and IgM−CD19+ pro-/pre-B cell populations (lower right panels). c, d Frequency of developing B cell in the spleen is reduced after infection. Mature B cells in the spleen were gated on B220+AA4.1+ cells. Developing B cells were gated on B220+AA4.1+ cells first (upper panels) and further analyzed for IgMhiCD23- TR1, IgMhiCD23+ TR2, and IgMloCD23+ TR3 developing B cells (lower right panels). Each group contained four to six mice. One of two independent experiments with similar results is shown. Values were shown as mean ± SEM. A two-tailed t test was used for statistical analysis. *, results differed from the control group; *P < 0.05; **P < 0.01; ***P < 0.001. #, results differed from the infected and treated with sesame oil group; # P < 0.05; ## P < 0.01; ### P < 0.001

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