Fig. 10

Cognitive deficits are not strongly associated with TSPO labeling. a DFP and VEH animals were conditioned 3, 8, and 19 days post-exposure using a single paired shock conditioning paradigm with foot shocks at 0.5 mA and then tested 24 h later for hippocampal-dependent contextual learning and memory (N = 10 VEH and 16 DFP-exposed animals). b Data from contextual fear conditioning in the subset of animals (N = 3 VEH and 6 DFP-exposed animals) also imaged by PET at 2, 7, and 21 days post-exposure. Data presented as the mean ± SD. *Significantly different from VEH on the same-day post-exposure as determined by two-way ANOVA followed by Holm-Sidak post hoc test at p < .05; **p < .01; ***p < .001. c Patterns of freezing behavior as a function of days post-exposure across different treatments and TSPO phenotypes, as described in Fig. 7. Each line represents the data from a single animal. d Adjusted odds ratio of freezing behavior in DFP-intoxicated rats relative to VEH with 95 % confidence interval. Confidence intervals not overlapping y = 1 (horizontal gray bar) indicate a significant difference relative to VEH (p < .05)