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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

Fig. 2

Acute DFP intoxication causes persistent neuronal degeneration in multiple brain regions. Rats injected with DFP (9 mg/kg ip) or an equal volume (300 μl) of vehicle (VEH) were euthanized at 1, 2, 3, 7, 14, and 21 days post-exposure to collect the brains for FluoroJade-B (FJB) staining. a Representative photomicrographs of FJB labeling in the thalamus (TH), CA1 region (CA1), and dentate gyrus (DG) of the hippocampus, as well as somatosensory (SS), piriform (PF), and entorhinal (ENT) cortices of the VEH and DFP-exposed rats at 7 days post-injection. Bar = 50 μm. b Dot plots of the log number of FJB-labeled cells in specific brain regions. Each dot represents the data from an individual animal, while the horizontal gray bars represent the geometric mean of FJB-labeled cells in that brain region at each time point. Note: No FJB-labeled cells were detected in any brain region of any VEH animal at any time point or in any DFP-exposed animals at 21 day post-exposure; similarly, no FJB-labeled cells were detected in the thalamus of one DFP-exposed animal at 2 days post-exposure, resulting in a geometric mean of negative infinity for these conditions. ***Significantly different from VEH at p < .001

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