Fig. 6

TSPO PET imaging detects neuroinflammation in DFP-intoxicated rats. TSPO expression was quantified in rats injected with the TSPO ligand [¹¹C]-PK11195. All animals were imaged before administration of VEH or DFP to collect baseline TSPO labeling; the same animals were imaged again at 2, 7, and 21 days post-injection with VEH or DFP. a Representative magnetic resonance image (MRI) was used for anatomic registry of PET images. b Overlay of MRI and [¹¹C]-PK11195 PET data for an animal with typical response at baseline and at 7 days post-DFP intoxication. c Longitudinal comparison of [¹¹C]-PK11195 uptake in a VEH (top row) vs. DFP-intoxicated animal (bottom row). Note: For the seventh day images, the upper limit of the color scale for PET imaging is increased to reflect a larger dynamic range of [¹¹C]-PK11195 uptake values at this time point. %ID/cc percent injected dose per cc