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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

Fig. 7

Patterns of TSPO labeling in VEH vs. DFP-intoxicated rats. Rats injected with the TSPO ligand [11C]-PK11195 were imaged prior to administration of VEH or DFP (day 0) and again at 2, 7, and 21 days post-exposure. Each plot represents an individual rat (with a unique identifier shown at the top of the plot) and each line within a plot represents a separate brain region (amygdala, dorsal lateral and medial dorsal thalamus, caudal and rostral hippocampus, piriform cortex, somatosensory cortex, reuniens nucleus, and septum). a The TSPO expression pattern for three VEH rats. b The predominant TSPO expression pattern imaged in DFP-intoxicated animals (six of nine) showing a predominant peak in TSPO labeling at 7 days post-exposure. Animal A08 died after baseline imaging, within hours after the DFP injection, and animal A03 died several days after the seventh day imaging. c Alternate TSPO expression phenotypes observed in three of the nine DFP-exposed rats. %ID/CC percent of injected dose per cc

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