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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

Fig. 3

Complement-independent loss of Müller cell AQP4 following intravitreal AQP4-IgG administration. a Immunofluorescence of the central retina at 5 days after intravitreal administration of AQP4-IgG (or control-IgG). Where indicated, rats were treated with cobra venom factor (CVF) to inactivate complement or administered AQP4-IgG-CDC (AQP4-IgG lacking complement effector function) in place of AQP4-IgG. In some studies, CD59−/− rats were administered AQP4-IgG. b Relative AQP4 (left) and GFAP (right) immunofluorescence in indicated retinal layers from sections as in (c) (mean ± S.E.M, 2 rats, 4 eyes per condition, *p < 0.05, **p < 0.01). c AQP4 and GFAP immunofluorescence at 5 days after intravitreal injection of saline control (top) or 5 μg LPS (bottom)

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