Fig. 5

Fundoscopy, OCT, and RGC count in rat eyes following intravitreal injection of AQP4-IgG. a Serial fundus photographs of individual rat eyes following intravitreal injection of AQP4-IgG (or control-IgG). b SD-OCT horizontal line scans through the optic nerve head in rat eyes for studies as in (a). OS/RPE outer segment/retinal pigment epithelium. c GCC (top) and total retinal (bottom) thicknesses before and at 5 and 30 days after intravitreal injection of AQP4-IgG (or control-IgG) (box and whisker plot with top line indicating maximum value, middle bar the mean, and lower line the minimum, mean ± S.E.M, 3 rats, 6 eyes per condition, *p < 0.05, **p < 0.01). d (Left) Brn3a immunofluorescence in mid-peripheral retina in flat mounts at 30 days after intravitreal injection of AQP4-IgG or control-IgG. (Right) Brn3a⁺ RGC cell counts (mean ± S.E.M, 2 rats, 4 eyes per condition, *p < 0.05)