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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

Fig. 6

AQP4-IgG reduces Müller cell AQP4 expression in retinal explant cultures by an endocytosis mechanism. a AQP4 and GS immunofluorescence in retinal explant cultures treated with 20 μg/mL AQP4-IgG (or control-IgG) for 24 h, in the absence or presence of 50 μM dynasore hydrate (dyn) or 10 μM chloroquine (clq). b Relative AQP4 immunofluorescence for experiments as in (a) (mean ± S.E.M, n = 6, *p < 0.05, **p < 0.01). c AQP4 immunofluorescence at high magnification for explant cultures treated for 4 h with AQP4-IgG (or control-IgG). White arrows indicate endocytic vesicles

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