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Table 5 TNF-α modulated expression of known TNF-α targeted genes (chemokines and adhesion molecules) in BMECs and SCMECs

From: Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells

   Basal TNF-α
   BMEC vs SCMEC BMEC SCMEC
Gene Probe 12 h 24 h 48 h 12 h 24 h 48 h
Ccl2 (a) A_42_P695401 0.6 7.4 4.8 2.2 3.5 3.5 3.1
Ccl2 (b) A_42_P695407 0.6 5.7 2.1 2.1 4.7 3.8 3.5
Ccl7 (a) A_44_P1022002 0.3 11.0 6.7 3.0 5.4 4.4 3.9
Ccl7 (b) A_44_P391296 0.3 14.0 6.2 2.8 5.5 5.0 4.5
Ccl5 A_44_P304323 0.2 7.8 11.0 16.7 6.5 7.7 8.0
Cxcl1 A_42_P473398 0.8 2.5 2.2 1.2 2.0 1.8 1.8
Cxcl2 A_44_P5151976 0.7 4.4 3.3 1.4 2.4 2.6 2.5
Cxcl3 A_44_P363116 0.5 9.8 7.5 2.7 6.1 5.0 3.9
Cxcl6 A_44_P270366 0.5 7.6 4.4 4.3 2.2 5.5 6.6
Cxcl10 A_44_P1039128 0.7 2.2 1.1 1.4 1.5 2.6 2.1
Cxcl11 A_44_P175495 0.4 8.6 7.8 5.6 5.9 8.9 6.4
Cxcl12 (a) A_44_P337351 0.9 3.1 2.7 0.8 3.2 2.7 2.0
Cxcl12 (b) A_44_P1034439 1.1 3.5 1.3 0.9 2.5 2.4 2.1
Icam1 A_43_P15253 0.8 3.0 3.4 0.8 2.0 3.8 2.3
Vcam1 A_42_P499158 1.0 7.7 2.0 1.4 3.0 2.4 2.3
  1. Ratio of the values in BMECs versus SCMECs and in TNF-α treated cultures after 12, 24, and 48 h versus non-treated cultures were filtered for FC ≥1.45 (in bold) or FC ≤0.69 (in bold and in italic)