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Table 5 TNF-α modulated expression of known TNF-α targeted genes (chemokines and adhesion molecules) in BMECs and SCMECs

From: Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells

  

Basal

TNF-α

  

BMEC vs SCMEC

BMEC

SCMEC

Gene

Probe

12 h

24 h

48 h

12 h

24 h

48 h

Ccl2 (a)

A_42_P695401

0.6

7.4

4.8

2.2

3.5

3.5

3.1

Ccl2 (b)

A_42_P695407

0.6

5.7

2.1

2.1

4.7

3.8

3.5

Ccl7 (a)

A_44_P1022002

0.3

11.0

6.7

3.0

5.4

4.4

3.9

Ccl7 (b)

A_44_P391296

0.3

14.0

6.2

2.8

5.5

5.0

4.5

Ccl5

A_44_P304323

0.2

7.8

11.0

16.7

6.5

7.7

8.0

Cxcl1

A_42_P473398

0.8

2.5

2.2

1.2

2.0

1.8

1.8

Cxcl2

A_44_P5151976

0.7

4.4

3.3

1.4

2.4

2.6

2.5

Cxcl3

A_44_P363116

0.5

9.8

7.5

2.7

6.1

5.0

3.9

Cxcl6

A_44_P270366

0.5

7.6

4.4

4.3

2.2

5.5

6.6

Cxcl10

A_44_P1039128

0.7

2.2

1.1

1.4

1.5

2.6

2.1

Cxcl11

A_44_P175495

0.4

8.6

7.8

5.6

5.9

8.9

6.4

Cxcl12 (a)

A_44_P337351

0.9

3.1

2.7

0.8

3.2

2.7

2.0

Cxcl12 (b)

A_44_P1034439

1.1

3.5

1.3

0.9

2.5

2.4

2.1

Icam1

A_43_P15253

0.8

3.0

3.4

0.8

2.0

3.8

2.3

Vcam1

A_42_P499158

1.0

7.7

2.0

1.4

3.0

2.4

2.3

  1. Ratio of the values in BMECs versus SCMECs and in TNF-α treated cultures after 12, 24, and 48 h versus non-treated cultures were filtered for FC ≥1.45 (in bold) or FC ≤0.69 (in bold and in italic)