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Table 6 TNF-α modulated expression of the top ten upregulated genes in BMECs (A) and SCMECs (B)

From: Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells

A   Basal TNF-α
   BMEC vs SCMEC BMEC SCMEC
Gene Probe 12 h 24 h 48 h 12 h 24 h 48 h
Mmp3 A_44_P318318 0.4 34.9 9.1 3.1 7.1 7.0 5.1
Mmp12 A_44_P555271 0.2 33.6 25.6 7.6 6.6 6.9 6.5
Mmp13 A_42_P606126 0.2 31.4 8.8 2.4 5.7 2.9 3.1
Mmp10 A_44_P404861 0.2 16.5 8.8 10.0 6.9 8.3 9.7
Cd69 A_43_P16166 0.5 14.7 11.6 3.2 8.4 6.7 4.8
Ubd A_42_P602724 0.5 14.6 10.1 8.7 4.2 7.4 5.0
Ccl7 A_44_P391296 0.3 13.6 6.2 2.8 5.5 5.0 4.5
Ass1 A_44_P391296 1.6 13.3 14.5 5.2 7.9 9.2 7.4
Ptgs2 A_44_P472989 1.0 12.5 10.7 2.9 5.2 6.5 3.6
Mmp9 A_42_P606126 0.3 12.1 22.2 22.6 6.4 5.2 7.5
B   Basal TNF-α
   BMEC vs SCMEC SCMEC BMEC
Gene Probe 12 h 24 h 48 h 12 h 24 h 48 h
Mmp9 A_44_P501112 0.5 10.2 7.9 9.9 11.7 20.6 17.6
Cd69 A_43_P16166 0.5 8.4 6.7 4.8 14.7 11.6 3.2
Ass1 A_44_P391296 1.6 7.9 9.2 7.4 13.3 14.5 5.2
Ptges A_43_P12079 1.1 7.3 5.9 4.9 7.2 6.1 4.3
Mmp3 A_44_P318318 0.4 7.1 7.0 5.1 34.9 9.1 3.1
Mmp10 A_44_P404861 0.2 6.9 8.3 9.7 16.5 8.8 10.0
Mmp12 A_44_P555271 0.2 6.6 6.9 6.5 33.6 25.6 7.6
Ccl5 A_44_P304323 0.2 6.5 7.7 8.0 7.8 11.0 16.7
Cxcl3 A_44_P363116 0.5 6.1 5.0 3.9 9.8 7.5 2.7
Cxcl11 A_44_P175495 0.4 5.9 8.9 6.4 8.6 7.8 5.6
  1. Ratio of the values in BMECs versus SCMECs and in TNF-α treated cultures after 12, 24, and 48 h versus non-treated cultures were filtered for FC ≥1.45 (in bold) or FC ≤0.69 (in bold and in italic)