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Table 6 TNF-α modulated expression of the top ten upregulated genes in BMECs (A) and SCMECs (B)

From: Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells

A

 

Basal

TNF-α

  

BMEC vs SCMEC

BMEC

SCMEC

Gene

Probe

12 h

24 h

48 h

12 h

24 h

48 h

Mmp3

A_44_P318318

0.4

34.9

9.1

3.1

7.1

7.0

5.1

Mmp12

A_44_P555271

0.2

33.6

25.6

7.6

6.6

6.9

6.5

Mmp13

A_42_P606126

0.2

31.4

8.8

2.4

5.7

2.9

3.1

Mmp10

A_44_P404861

0.2

16.5

8.8

10.0

6.9

8.3

9.7

Cd69

A_43_P16166

0.5

14.7

11.6

3.2

8.4

6.7

4.8

Ubd

A_42_P602724

0.5

14.6

10.1

8.7

4.2

7.4

5.0

Ccl7

A_44_P391296

0.3

13.6

6.2

2.8

5.5

5.0

4.5

Ass1

A_44_P391296

1.6

13.3

14.5

5.2

7.9

9.2

7.4

Ptgs2

A_44_P472989

1.0

12.5

10.7

2.9

5.2

6.5

3.6

Mmp9

A_42_P606126

0.3

12.1

22.2

22.6

6.4

5.2

7.5

B

 

Basal

TNF-α

  

BMEC vs SCMEC

SCMEC

BMEC

Gene

Probe

12 h

24 h

48 h

12 h

24 h

48 h

Mmp9

A_44_P501112

0.5

10.2

7.9

9.9

11.7

20.6

17.6

Cd69

A_43_P16166

0.5

8.4

6.7

4.8

14.7

11.6

3.2

Ass1

A_44_P391296

1.6

7.9

9.2

7.4

13.3

14.5

5.2

Ptges

A_43_P12079

1.1

7.3

5.9

4.9

7.2

6.1

4.3

Mmp3

A_44_P318318

0.4

7.1

7.0

5.1

34.9

9.1

3.1

Mmp10

A_44_P404861

0.2

6.9

8.3

9.7

16.5

8.8

10.0

Mmp12

A_44_P555271

0.2

6.6

6.9

6.5

33.6

25.6

7.6

Ccl5

A_44_P304323

0.2

6.5

7.7

8.0

7.8

11.0

16.7

Cxcl3

A_44_P363116

0.5

6.1

5.0

3.9

9.8

7.5

2.7

Cxcl11

A_44_P175495

0.4

5.9

8.9

6.4

8.6

7.8

5.6

  1. Ratio of the values in BMECs versus SCMECs and in TNF-α treated cultures after 12, 24, and 48 h versus non-treated cultures were filtered for FC ≥1.45 (in bold) or FC ≤0.69 (in bold and in italic)