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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

Fig. 1

Spatio-temporal profile of CX3CR1GFP/+ and CCR2RFP/+ Mo/MΦ infiltration after stroke. a Anatomical localization of CCR2-RFP (red) and CX3CR1-GFP (green) cells infiltrating the ischemic hemisphere in coronal brain sections of CCR2RFP/+CX3CR1GFP/+chimeric mice 3, 14, or 28 days after MCAo and in sham mice. Infarct volume was outlined in serial cresyl violet stained sections 3 days after MCAo and overlaid on fluorescent images (dotted line). b Quantification of infiltrating CX3CR1GFP/+ and CCR2RFP/+ cells in sham mice and stroke mice 1, 2, 3, 5, 7, 14, and 28 days after MCAo (n = 3–4 mice/group). *p < 0.05 and ***p < 0.001 vs. Sham. c Quantification of infiltrating CX3CR1GFP/+CCR2RFP/+ double-positive cells in sham mice and stroke mice 1, 2, 3, 5, 7, 14, and 28 days after MCAo (n = 3–4 mice/group). **p < 0.01 vs. Sham. d Diagram depicting the brain-sectioning method. The brain was sectioned in 12 coronal slices at 600-μm intervals, beginning from the frontal pole and proceeding in caudal direction

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