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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling

Fig. 6

Activation of microglia suppressed by synaptamide in the LPS-challenged mouse brain. Brain sections (30-μm thick) were prepared 24 h after LPS and/or synaptamide injection, and immunostaining for Iba-1 and GFAP was performed. Iba-1 (a) and GFAP (c) images from whole sections (top panel) and higher magnification of the rectangular area (×20, bottom panel) in the cerebral cortex (CX) and corpus callosum (CC) are presented, along with quantification results of Iba-1 (b) and GFAP (c). The Iba-1 and GFAP protein levels are shown by the western blot analysis of the whole brain extract (d). Values are presented as mean ± SEM from four mice. Means designated with the same letter are not significantly different. Scale bar: 100 μm (a, c)

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