Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Fig. 7

Quantification of myelin coverage and oligodendrocyte density following injection of IL13-MSC on the right and left sides of the splenium in CPZ-treated mice. a Upper row: representative overview images of the splenium of the corpus callosum stained for MBP (red) in control, CPZ-treated mice and CPZ-treated mice with IL13-MSC grafts. The areas which were analysed are delineated by a dotted line. Scale bar indicates 200Ā Ī¼m. Lower row: dot plots showing the coverage percentage of MBP over the whole splenium (left graph), the left side of the splenium (middle graph) and the right side of the splenium (right graph) for each experimental group. The mean of each group is represented by a horizontal line. Significant differences are indicated with two (p value ā‰¤0.01) or three (p value ā‰¤0.001) asterisks. b Upper row: representative overview images of the splenium of the corpus callosum stained for CC1+ oligodendrocytes (red) in control, CPZ-treated mice and CPZ-treated mice with IL13-MSC grafts. The areas which were analysed are delineated by a dotted line. Scale bar indicates 100Ā Ī¼m. Lower row: dot plots showing the cell density (cells/mm2) of CC1+ oligodendrocytes over the whole splenium (left graph), the left side of the splenium (middle graph) and the right side of the splenium (right graph) for each experimental group. The mean of each group is represented by a horizontal line. Significant differences are indicated with two (p value ā‰¤0.01) or three (p value ā‰¤0.001) asterisks. c Dot plots showing the correlation between MBP coverage percentage and CC1+ oligodendrocyte cell density (left graph), MBP coverage percentage and T 2 relaxation times (middle graph), CC1+ oligodendrocyte cell density and T 2 relaxation times (right graph) in the whole splenium for each experimental group. Spearmanā€™s correlation coefficient (r) is presented on each graph. Data points indicated in red on (a and b) correspond with the representative MRI images provided in Fig.Ā 6a, b and with the representative histological images shown in (a and b)

Back to article page