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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis

Fig. 5

Early regulation of CSF1 in EAE. a Schematic illustration of CSF1 regulation in all the biological samples analyzed on Excel: the XY scatter option is chosen and under the chart subtypes, the option connecting the points with smooth lines with markers is selected. The amount of CSF1 in plasma (b) and CSF (c) in the control, EAE, and adjuvant groups are reported. Results are presented as individual values (pg/ml), and the mean ± SD is also shown. d The expression level of mRNA of CSF1 is reported in the clustergram, based on heat map with dendrograms, indicating the co-regulation across the different groups (ej) k CSF1-immunostaining in the white matter of control and EAE experimental groups: 1, 5, 8, 11, and 18 DPI. The immunoreactive area of CSF1 in EAE rats compared to controls. Double labeling for CSF1 and oligodendrocytes marker (CNPase) and GFAP in the EAE group 1 and 11 DPI (l, m and n, o, consecutively). Statistical analysis: one-way ANOVA and Dunnett’s multiple comparison test (*P < 0.05, ***P < 0.001, ****P < 0.0001)

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