Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

Abbasi, Asghar; de Paula Vieira, Rodolfo; Bischof, Felix; Walter, Michael; Movassaghi, Masoud; Berchtold, Nicole C.; Niess, Andreas M.; Cotman, Carl W.; Northoff, Hinnak

doi:10.1186/s12974-016-0758-5

Journal of Neuroinflammation

Table 3 Most differentially regulated genes between sexes in each time-point (t × g alg.) in both cultures.The fold change calculated based on log 2 (men_{post ‐ exercise – pre ‐ exercise}) — (women_{post ‐ exercise – pre ‐ exercise})

From: Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

Gene ID	Gene symbol	Log2 FC inUnstimulated culture			Log2 FC in LPS-stimulated culture
Gene ID	Gene symbol	T1-T0	T2-T0	T3-T0	T1-T0	T2-T0	T3-T0
11721945_a_at	MRVI1	1.967	0.428	0.424	1.917	0.866	1.298
11716974_a_at	PDK4	1.817	0.527	1.132	0.328	0.109	0.075
11757733_s_at	XIST	1.590	1.0798	−0.715	0.1970	0.277	−0.549
11721216_s_at	TMEM106B	1.477	−0.309	0.474	1.912	0.735	1.024
11764064_s_at	CYorf15B	−1.964	−1.345	−0.306	−1.848	−1.350	0.025
11754026_a_at	IL8	−1.795	−2.040	−0.863	−0.527	0.453	0.133
11736405_a_at	DNMT1	−1.481	−1.246	−0.369	0.478	−0.292	0.395
11726814_x_at	KDM5D	−1.405	−0.810	−0.131	−0.922	−0.988	−0.026
11729424_s_at	CCRL2	0.841	1.282	0.764	0.897	0.736	0.557
11757485_x_at	FAM129B	0.533	1.269	0.744	0.532	0.459	0.387
11759616_at	VASH1	0.567	1.053	0.843	0.428	0.072	0.191
11720029_a_at	LDLR	0.123	1.027	0.910	0.136	0.000	0.626
11744660_s_at	CCL4L1///CCL4L2	−1.334	−1.948	−0.062	−0.047	0.183	−0.015
11723679_s_at	CD69	−0.337	−1.436	−0.780	−0.346	−0.102	−0.144
11763717_a_at	CDKN1C	−0.754	0.253	1.168	−1.037	−0.917	0.202
11755211_a_at	DICER1	−0.043	0.058	1.042	−0.152	−0.165	0.214
11738041_x_at	TNIP3	−0.025	0.020	−0.028	3.371	1.228	0.582
11722015_at	OLR1	−0.081	−0.165	−0.061	2.265	2.042	1.591
11756590_a_at	KMO	−0.338	−0.010	−0.287	1.979	1.527	1.174
11754526_a_at	PTGES	0.154	0.116	0.019	1.954	1.192	1.158
11728477_at	CXCL3	−0.136	−0.008	−0.095	−2.446	−0.046	−1.031
11758472_s_at	RICTOR	−1.204	−0.159	−0.631	−2.035	−0.308	−0.766
11732719_at	EREG	0.049	0.433	−0.041	−1.819	−1.211	−0.983
11735242_s_at	ZC3H12C	0.020	0.344	−0.114	1.948	1.643	0.715
11727181_a_at	SKIL	0.226	0.010	0.3023	0.869	1.526	0.598
11720298_at	CXCL10	0.016	−0.056	0.109	1.500	1.432	1.340
11746463_a_at	IL6	0.313	0.259	0.373	1.063	1.228	1.165
11736090_a_at	OLIG2	−0.384	−0.563	−0.365	−1.087	−1.499	0.054
11757044_x_at	C7orf68	−0.539	−0.187	−0.154	−1.008	−1.426	−0.203
11716496_s_at	CHMP4B	0.6431	−0.138	0.267	1.844	1.212	1.720
11718394_at	JUN	0.431	−0.152	0.560	1.154	0.184	1.562
11740393_at	TNFRSF9	0.063	0.452	0.648	0.967	1.144	1.536
11752419_a_at	HIVEP1	0.170	−0.106	−0.079	1.826	1.184	1.416
11718759_x_at	HIF1A	0.370	−0.333	−0.160	0.263	1.077	1.395
11721034_at	PPP1R3B	0.584	0.183	−0.198	−1.145	−0.330	−1.121
11721542_a_at	MARCH9	−0.309	0.254	−0.039	−0.614	−0.808	−1.118
11718452_at	AXIN2	−0.449	−0.155	−0.886	−0.555	−0.551	−1.094
11720062_s_at	IER3	1.038	0.375	0.825	0.092	0.048	0.135
11750167_a_at	CAPN2	−0.999	−0.637	−0.153	−0.630	−0.144	−0.318
11717656_a_at	SPRED2	1.066	0.514	0.309	0.979	0.953	0.038
11719154_a_at	DRAM1	0.395	−0.095	−0.152	1.344	1.036	0.927

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ISSN: 1742-2094

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