Fig. 1

Flow cytometric analysis in Aβ⁰.β2m⁰.Hβ2m⁺.A11⁺ and Aβ⁰.β2m⁰.Hβ2m⁺.B27⁺ mice. Cell surface expression was examined by antibodies to Aβ (Aβ-163), Hβ2m (L-368), H2-K^b (B8-24-3) and H2-D^b (172-93.1). Controls were B10 (Aβ⁺.Hβ2m⁻), Aβ⁰, K^b0.D^b0.β2m⁰.Hβ2m⁺, and C57BL/6 (K^b+.D^b+) mice. In each panel, the gray histogram represents negative control, the green histogram represents a positive control, and the red and blue histograms represent Aβ⁰.β2m⁰.Hβ2m⁺.A11⁺ and Aβ⁰.β2m⁰.Hβ2m⁺.B27⁺ mice, respectively. Non-expression of Aβ (a) and expression of Hβ2m (b), H2-K^b (c), and H2-D^b (d) in transgenic human class I mice is shown