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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

Fig. 11

Metabolic activity subnetwork output from mummichog analysis presented in Fig. 9a, b (representative of purine and pyrimidine pathways) for the brain and vascular sides of the NVU stimulated with 100 ng/mL cocktail of IL-1, TNF-α, and MCP-1,2 for 24 h. Feature m/z values and significance measurements were used to predict metabolic activity networks without the use of conventional MS/MS identification workflows. Metabolites are colored blue for negative fold change or red for positive fold change, with the color intensity representing the magnitude of fold change and the size representing the statistical significance ((−log10(p value))

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