Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

Fig. 2

Blood-brain barrier transport of inflammatory signals. a Concentration in pg/ml in effluent going into an empty bioreactor and effluent coming out after 24 h of continuous perfusion at 2 μl/min. b Concentration of LPS in vascular and brain chambers over time. At 24 h, the brain is significantly lower than vascular (p = .0035, N = 8). c ELISA of TNF-α in NVU before and after treatment of the vascular side only with cytokine cocktail containing 100 ng/ml TNF-α, IL-1β, and MCP1,2 shows 31% transport of TNF-α to neuronal/brain chamber. d ELISA of IL-1β in NVU before and after treatment of the vascular side only with cytokine cocktail containing 100 ng/ml TNF-α, IL-1β, and MCP1,2 shows 36% transport of IL-1β to neuronal/brain chamber (N = 8)

Back to article page