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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

Fig. 3

FITC-dextran diffusion across the BBB and tight junction staining in response to inflammatory stimulation over time. a FITC-dextran diffusion across the BBB is significantly increased at 6 h (p = .05, N = 7) and reduced from the 6-h point at 24 h (p = .05, N = 7). b FITC-dextran diffusion across the BBB is significantly increased 24 h after start of cytokine cocktail exposure (p = .01, N = 4). c TEER of dose- and time-dependent effect with LPS response. d Claudin-5 staining of tight junctions shows dose- and time-dependent response, with staining decreasing at early time points with dose and increasing at later time points with dose. e ZO-1 staining of tight junctions shows dose- and time-dependent response, with staining decreasing at early time points with dose and increasing at later time points with dose. f Mean grayscale intensity of the images such as those in b and c for Claudin-5 and ZO-1 release in response to LPS concentration over time

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