Fig 6

UPLC-IM-MS global metabolomic profile analysis upon cytokine cocktail treatment. a Global principal component analysis (PCA) of cytokine cocktail-stimulated (0 and 24 h) sample types (brain chamber) illustrating that two distinct metabolic signatures or profiles were observed in the UPLC-IM-MS analysis. b Volcano plot comparing basal conditions (no cytokine cocktail treatment) at 0 and 24 h as well as treated (100 ng/ml cocktail) in the vascular chamber. c Volcano plot comparing basal conditions (no cytokine cocktail treatment) at 0 and 24 h as well as treated (100 ng/ml cocktail) in the brain chamber