Fig. 7

Comparison of metabolites significantly affected by LPS and cytokine cocktail over time in both the vascular and brain chambers. a Venn diagram of metabolites/compounds observed for the brain side of the NVU system in response to stimulation with LPS over time (6 and 24 h). b Venn diagram of metabolites/compounds observed for the vascular side of the NVU system in response to stimulation with LPS over time (6 and 24 h). c Graphical representation of the increase in the total number of features for the brain side. d Graphical representation of the increase in the total number of features for the vascular side (significant criteria: p ≤ 0.05 and fold change ≥│2│). e Venn diagram of metabolites/compounds observed for the brain side of the NVU system in response to stimulation with cytokine cocktail (24 h). f Venn diagram of metabolites/compounds observed for the vascular side of the NVU system in response to stimulation with cytokine cocktail (24 h). g Graphical representation of the increase in the total number of features for the brain side. h Graphical representation of the increase in the total number of features for the vascular side (significant criteria: p ≤ 0.05 and fold change ≥│2│)