Fig. 8
Comparison of the number of metabolites significantly affected by either LPS or cytokine cocktail over time and in both the vascular and brain chambers. a Statistically significant metabolites/compounds observed for the brain side and the vascular side of the NVU system in response to stimulation with 100 μg/mL LPS after 6 h of exposure. b Statistically significant metabolites/compounds observed for the brain side and the vascular side of the NVU system in response to stimulation with 100 μg/mL LPS after 24 h of exposure. c Graphical representation of the increase in the total number of features for the brain side and the vascular side at the 6-h time point. d Graphical representation of the increase in the total number of metabolites/compounds for the brain side and the vascular side at the 24-h time point (significant criteria: p ≤ 0.05 and fold change ≥│2│). e Statistically significant metabolites/compounds observed for the brain side and the vascular side of the NVU system under control conditions. f Statistically significant metabolites/compounds observed for the brain side and the vascular side of the NVU system in response to stimulation with 100 ng/mL cytokine cocktail after 24 h of exposure. g Graphical representation of the increase in the total number of features for the brain side and the vascular side under control conditions. h Graphical representation of the increase in the total number of metabolites/compounds for the brain side and the vascular side at the 24-h time point (significant criteria: p ≤ 0.05 and fold change ≥│2│)