Fig. 6
From: Tollip, an early regulator of the acute inflammatory response in the substantia nigra
8-oxo-2′-deoxyguanosine (8-oxo-dG) immunostaining is increased in midbrain of Tollip-deficient mice 6 h after LPS intra-nigral injection. a Representative 8-oxo-DG immunostaining in the non-injected and LPS (0.1 μg)-injected side in WT and Tollip KO 15-month-old male mice. Magnification = ×40. Scale bar = 30 μm. b Quantification of fluorescence intensity performed on two fields in the injected area, on three sections per animal (n = 4 in WT and 5 mice in KO group). Box and whiskers show median, min., and max. values, 25th and 75th percentiles. Plots represent individual values and means are represented as a “+.” # P < 0.05; ## P < 0.01 versus non-injected side and ** P < 0.01; *** P < 0.001 versus WT mice. Two-way ANOVA followed by a Tukey’s post hoc test