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Table 1 Blockade of IL-7 receptor signaling decreases T cell encephalitogenicity

From: Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα

Conditions

Number of mice

Incidence of EAE (%)

Mean day of onset of EAE mice

Mean peak clinical score of all mice

Mean peak clinical score of EAE mice

Ag only

11

7/11 (64%)

9

1.64a

2.57

Ag + IL-7

11

9/11 (82%)

10

2.18b

2.67

Ag + αIL-7Rα

12

4/12 (33%)

11.5

0.58a, b

1.75

  1. aMean peak clinical score of all mice: Ag + αIL-7Rα vs Ag only (P < 0.05)
  2. bMean peak clinical score of all mice: Ag + αIL-7Rα vs Ag + IL-7 (P < 0.05)
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Journal of Neuroinflammation

ISSN: 1742-2094