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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury

Fig. 4

Hypobaria exposure upregulates the expression of PCNA in the ipsilateral cortex and hippocampus at 30 days after TBI. a Representative immunofluorescent staining for PCNA (green) and DAPI (blue). b, c Quantification of pixel intensity for PCNA revealed significant increases in the TBI + Veh + HB group in contrast to the TBI-alone tissue. A significant decrease of cyclin D1 expression was observed in the CR8 treatment group in comparison to the TBI/Veh/HB group. N = 4 (sham), 6 (TBI), 6 (TBI/Veh/HB), 6 (TBI/CR8/HB). *p < 0.05, TBI vs. sham injury; $$ p < 0.01, TBI/Veh/HB vs. TBI; # p < 0.05, ### p < 0.001, TBI/CR8/HB vs. TBI/Veh/HB. d Most of the PCNA+ cells (green) in the injured cortex were co-labeled with galectin 3-expressing microglia/macrophages (red; DAPI, blue). Scale bar = 50 μm in a and 25 μm in d

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