Fig. 8From: Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injuryHypobaria exposure after TBI increases the expression of NADPH oxidase membrane component gp91phox. a Representative immunofluorescent staining for gp91phox (red) and DAPI (blue) in the ipsilateral cortex and hippocampus at 30 days after TBI. b, c Quantification of gp91phox-positive cells revealed significant increases in the TBI + Veh + HB group in contrast to the TBI-alone tissue. A significant decrease of gp91phox-positive cells was observed in the CR8 treatment group in comparison to the TBI/Veh/HB group. N = 4 (sham), 6 (TBI), 6 (TBI/Veh/HB), 6 (TBI/CR8/HB). *p < 0.05, TBI vs. sham injury; $$ p < 0.01, TBI/Veh/HB vs. TBI; ## p < 0.01, ### p < 0.001, TBI/CR8/HB vs. TBI/Veh/HB. d gp91phox-positive cells (red) in the injured cortex were co-labeled with Iba-1+ microglia/macrophages (green; DAPI, blue). Scale bar = 50 μm in a and 25 μm in d Back to article page