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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury

Fig. 8

Hypobaria exposure after TBI increases the expression of NADPH oxidase membrane component gp91phox. a Representative immunofluorescent staining for gp91phox (red) and DAPI (blue) in the ipsilateral cortex and hippocampus at 30 days after TBI. b, c Quantification of gp91phox-positive cells revealed significant increases in the TBI + Veh + HB group in contrast to the TBI-alone tissue. A significant decrease of gp91phox-positive cells was observed in the CR8 treatment group in comparison to the TBI/Veh/HB group. N = 4 (sham), 6 (TBI), 6 (TBI/Veh/HB), 6 (TBI/CR8/HB). *p < 0.05, TBI vs. sham injury; $$ p < 0.01, TBI/Veh/HB vs. TBI; ## p < 0.01, ### p < 0.001, TBI/CR8/HB vs. TBI/Veh/HB. d gp91phox-positive cells (red) in the injured cortex were co-labeled with Iba-1+ microglia/macrophages (green; DAPI, blue). Scale bar = 50 μm in a and 25 μm in d

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