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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Fig. 2

Functional role of MASP-2 in pneumococcal meningitis mouse model. Kaplan-Meier curve showing increased survival in Masp2 −/− mice during pneumococcal meningitis (a). Cytokines and complement levels were measured in brain. Masp2 −/− mice had significantly lower brain levels of IL-1β, IL-10, and TNF-α 30 h after infection (bd). Brain levels of C5b-9 were similar between Masp2 −/− and WT mice (e). Data are given as medians and 75th quartile; P values were determined with the Mann-Whitney U test

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