Fig. 3

The effect of adjuvant treatment with the MASP-2 antibodies on clinical severity and survival in experimental pneumococcal meningitis. Kaplan-Meier curve of WT mice with pneumococcal meningitis treated intraperitoneally 20 h after infection with ceftriaxone (100 mg/kg) in combination with adjuvant treatment and observed for 68 h (a). Adjuvant treatment consisted of sterile saline, isotype antibodies (MAB205P, 1 mg/kg), or MASP-2 antibodies (D04211, 1 mg/kg). There was no difference in survival between groups. P values were determined with the log-rank test. Clinical severity scores for MASP-2 antibody-treated mice increased slower as compared to saline- (0.017 vs. 0.103 points/h) and isotype antibody (0.0017 vs. 0.080 points/h)-treated mice (b). P values were determined using linear mixed models with group/treatment, time, and their interaction as effects