Skip to main content

Table 1 Clinical characteristics of 792 pneumococcal meningitis patients with and without CSF available

From: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Characteristics Patients with CSF (n = 307) Patients without CSF (n = 485) P value
Age (year) 62 (51–70) 61 (51–70) 0.96
Male 142/307 (46) 242/458 (53) 0.32
Duration of symptoms <24 h 140/297 (47) 233/464 (50) 0.41
Predisposing conditions 202/307 (66) 318/485 (66) 0.95
 Otitis or sinusitis 121/306 (40) 205/483 (42) 0.42
 Pneumonia 28/298 (9) 53/461 (11) 0.36
 Immunocompromised 96/307 (31) 119/485 (25) 0.04
Symptoms and signs on presentation a d  
 Headache 221/267 (83) 345/415 (83) 0.90
 Neck stiffness 224/297 (75) 340/447 (76) 0.84
 Systolic blood pressure (mmHg) 148 (130–169) 145 (126–165) 0.29
 Heart rate (bpm) 100 (86–112) 100 (88–115) 0.78
 Body temperature (°C) 39.0 (38.2–39.7) 39.0 (38.0–39.7) 0.26
Score on Glascow Coma Scale 10 (8–13)b 10 (9–13)e 0.70
 <8 indicating coma 40/306 (13) 80/483 (17) 0.18
Focal neurologic deficits 90/306 (29) 139/481 (29) 0.88
Indexes of CSF inflammation c f  
 Opening pressure 37 (27–43) 35 (28–45) 0.66
 White blood cell count (/mm3) 2560 (460–6667) 2567 (516–7048) 0.60
 White blood cell count <1000/mm3 103/295 (35) 153/465 (33) 0.57
 Protein (g/l) 4.1 (2.5–6.0) 4.2 (2.5–6.2) 0.61
 CSF blood glucose ratio 0.02 (0.00–0.23) 0.01 (0.00–0.16) 0.06
Positive blood culture 215/267 (81) 341/423 (81) 0.98
Score on Glasgow Outcome Scale
 1—death 43/307 (14) 101/485 (21) 0.02
 2—vegetative state 0/307 (0) 1/485 (0) 0.43
 3—severe disability 14/307 (5) 27/485 (6) 0.53
 4—moderate disability 64/307 (21) 77/485 (16) 0.08
 5—good recovery 186/307 (61) 279/485 (58) 0.39
  1. Data are number/number evaluated (percentage), and continuous data are mean ± SD
  2. aSystolic blood pressure was evaluated in 301 patients, heart rate was evaluated in 298 patients, and temperature was evaluated in 304 patients
  3. bScore on Glasgow Coma Scale was evaluated in 306 patients
  4. cCSF opening pressure was evaluated in 76 patients, CSF white blood cell count was evaluated in 295 patients, CSF protein was evaluated in 293 patients, and CSF blood glucose ratio was evaluated in 288 patients
  5. dSystolic blood pressure was evaluated in 477 patients, heart rate was evaluated in 472 patients, and temperature was evaluated in 478 patients
  6. eScore on Glasgow Coma Scale was evaluated in 483 patients
  7. fCSF opening pressure was evaluated in 89 patients, CSF white blood cell count was evaluated in 464 patients, CSF protein was evaluated in 464 patients, and CSF blood glucose ratio was evaluated in 456 patients