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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity

Fig. 4

The impact of DHA-injected icv on the activity of the RvD2 system in the hypothalamus. Six-week-old Swiss mice were included in the study and fed a HF diet for 4 weeks before intracerebroventricular (icv) cannulation; after 1 week, mice were randomly selected for either saline (2 μl) or different amounts of DHA (2 μl) icv treatment for 4 days; some mice were fed on chow throughout the experimental period (CT) (a). At the end of the experimental period, hypothalamic RNA was extracted and employed in real-time PCR determinations of phospholipase A2 (PLA2) (b), 15-lipoxigenase (15-LOX) (c), 5-lipoxigenase (5-LOX) (d), GPR18 (e), interleukin-6 (IL6) (f) and interleukin-10 (IL10) (g). Cumulative food intake (h) and body mass change (i) were evaluated during the experimental period. In all experiments, n = 7. *p < 0.05 vs. CT

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