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Table 1 Summary of statistical tests of null changes between baseline and 52 weeks and tests of null differences at baseline using all detected molecules in CSF of patients treated with placebo (N = 19) or resveratrol (N = 19)

From: Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Analytes Between baseline and 52 weeks At baseline
Paired t test Unpaired t test Wilcoxon signed rank test Active vs placebo
Placebo Active   Placebo Active Unpaired t test (unequal) Unpaired t test (equal) Wilcoxon signed rank test
Aβ40 0.0031** 0.0014** 0.0784 0.0066** 0.0029** 0.3579 0.3587 0.5284
Aβ42 0.0112* 0.0027** 0.0784 0.0105* 0.0034** 0.3764 0.3739 0.4986
pTau 181 0.0665 0.6498 0.4409 0.0649 0.2891 0.7043 0.7044 0.9319
tTau 0.91 0.3673 0.4614 0.9622 0.2163 0.5769 0.5638 0.9373
MMP-9 0.0474* 0.0027** 0.0241* 0.0771 0.0034** 0.8751 0.8737 1.0000
MMP-3 0.6098 0.5437 0.942 0.5016 0.6848 0.6911 0.6882 0.9311
MMP-2 0.5781 0.2322 0.9759 0.7049 0.3388 0.8828 0.8828 0.8509
MMP-10 0.4965 0.3175 0.9999 0.9341 0.5935 0.9415 0.9410 0.6807
FGF-2 0.3676 0.0248* 0.269 0.2128 0.0273* 0.6751 0.6774 0.5508
TGFα 0.8693 0.0829 0.4257 0.61 0.2324 0.5571 0.5519 0.9843
G-CSF 0.0532 0.1196 0.6722 0.0942 0.1563 0.2042 0.2422 0.4195
MCP-3 0.4751 0.0802 0.2922 0.5625 0.1094 0.2366 0.2305 0.2948
MDC 0.8121 0.001*** 0.0505 0.8938 0.0009*** 0.0458 0.0566 0.0678
PDGF-AA 0.9866 0.1106 0.0728 0.804 0.0787 0.9883 0.9886 0.8957
IL-4 0.9647 0.0085** 0.1828 0.6875 0.0167* 0.0860 0.0992 0.0748
PDGF-AB/BB 0.1752 0.4337 0.3356 0.0463* 0.057 0.6349 0.6261 0.7881
IL-8 0.262 0.1177 0.1594 0.57 0.0465* 0.9648 0.9648 0.6450
Flt-3L 0.9602 0.1132 0.5639 0.8498 0.155 0.8880 0.8880 0.8109
Fractalkine 0.791 0.4409 0.5973 0.6701 0.9382 0.4541 0.4543 0.8641
IFNα2 0.8832 0.4182 0.2943 0.8361 0.7547 0.8727 0.8729 0.6194
IL-15 0.9469 0.3587 0.3867 0.816 0.4263 0.7049 0.7029 0.6813
IL-7 0.8148 0.4458 0.3147 0.8384 1 0.4650 0.4553 0.4305
IP-10 0.2769 0.4091 0.405 0.6026 0.7368 0.3900 0.3918 0.8509
MCP-1 0.8089 0.5809 0.7419 0.421 0.8971 0.8650 0.8650 0.9864
MIP-1b 0.3973 0.2909 0.6174 0.3621 0.2188 0.7722 0.7632 0.8401
  1. Indicated in bold typeface represents significant associations (at level 0.05) after the Benjamini–Hochberg correction
  2. *p<0.05
  3. **p<0.1
  4. ***p<0.001