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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity

Fig. 7

Effect of APAP on the expression of Bax/Bcl-2 and neuron apoptosis in mice with hippocampal impairment. ac Protein bands on the gel and their relative intensities on postoperative day 1. df The expression levels of Bax/Bcl-2 proteins were normalized to that of β-actin as an internal control. g CA1, CA3 and DG regions of hippocampal from indicated group of mice. TUNEL staining demonstrated neuron apoptosis on postoperative day 1. h The number of hippocampal apoptotic neurons on postoperative day 1 under ×400 magnification. Scale bars: ×100, 200 μm; ×400, 50 μm. Data are expressed as the mean ± SE (n = 6). **P < 0.01, ***P < 0.001 vs. CON group; # P < 0.05, ## P < 0.01, ### P < 0.001 vs. LPS group. APAP acetaminophen, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error

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