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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

Fig. 4

PDTC inhibits the enhancement effect of maternal separation on NF-κB activation and the release of pro-inflammatory cytokines induced by sevoflurane in MS rats. PDTC or vehicle (saline) was given to rats intraperitoneally 30 min before exposure to sevoflurane. a PDTC pretreatment decreased the nuclear NF-κB p65 protein levels in the hippocampus 12 h after sevoflurane anesthesia. b PDTC pretreatment decreased TNF-α levels in the hippocampus 12 h after sevoflurane anesthesia. c PDTC pretreatment decreased IL-1β levels in the hippocampus 12 h after sevoflurane anesthesia. d PDTC pretreatment decreased IL-6 levels in the hippocampus 12 h after sevoflurane anesthesia. ** P < 0.01 versus saline. Error bars represent the means ± SD (n = 6). Statistical analyses were performed with Student’s two-sample t test

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Journal of Neuroinflammation

ISSN: 1742-2094