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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

Fig. 5

Maternal separation attenuated the expression of GR and increased the percentage of methylated clones within the exon 17 glucocorticoid receptor promoter region from the hippocampal tissues of adult rats. a GR protein levels in the hippocampal tissues of MS rats were lower compared with those of control rats. b qRT-PCR (GAPDH as an internal control) showed that MS decreased the mRNA levels of GR in the hippocampus compared with the control conditions. c The complete sequence map of exon 17 of the GR promoter region (bold), including the 17 CpG dinucleotides (superscript numbers). d The frequency of methylation observed at each CpG site in the exon 17 GR promoter region showed that MS rats have a higher percentage of methylated clones than control rats. * P < 0.05, ** P < 0.01 versus control. Error bars represent the means ± SD (n = 6). Statistical analyses were performed with Student’s two-sample t test

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Journal of Neuroinflammation

ISSN: 1742-2094