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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism

Fig. 11

WWL70 treatment attenuated PGE2 production in EAE mouse brain. EAE mouse model was induced by immunization with the MOG35–55 peptide. Intraperitoneal injection of WWL70 was started at the disease onset and then once a day until the end of experiment. The clinical scores at day 21 in EAE mice in vehicle and drug-treated groups were shown (a). Mouse forebrain was dissected and used for measuring PGE2 concentration (n = 10–11) (b). Microsome fraction prepared from the brain tissue was applied to PGE2 synthetic activity assay (n = 4–5) (c). Data are represented as mean ± SD. Single, double, and triple asterisks denote p < 0.05, 0.01, and 0.001, respectively

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