Fig. 11

WWL70 treatment attenuated PGE₂ production in EAE mouse brain. EAE mouse model was induced by immunization with the MOG_35–55 peptide. Intraperitoneal injection of WWL70 was started at the disease onset and then once a day until the end of experiment. The clinical scores at day 21 in EAE mice in vehicle and drug-treated groups were shown (a). Mouse forebrain was dissected and used for measuring PGE₂ concentration (n = 10–11) (b). Microsome fraction prepared from the brain tissue was applied to PGE₂ synthetic activity assay (n = 4–5) (c). Data are represented as mean ± SD. Single, double, and triple asterisks denote p < 0.05, 0.01, and 0.001, respectively