Fig. 12

Potential actions of WWL70 on PGE₂ and PGE₂-G production in microglia. 2-AG is mainly metabolized to arachidonic acid, which in turn converts to PGE₂ by catalysis of COX-1/2 and mPGESs. WWL70 inhibits ABHD6 thereby increasing the levels of 2-AG and reduces the production of PGE₂ by inhibiting PGE₂ synthetic enzymes. 2-AG can also be oxygenated by COX-2 and then converted to PGE₂ glycerol ester by mPGESs, which is also inhibited by WWL70