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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism

Fig. 9

WWL70 inhibited microsomal PGE2 biosynthetic pathway. Microsome from LPS-activated BV2 cells was pre-incubated with WWL70 (3 μM), the mPGES-1 inhibitor MK886 (3 μM), the COX-1 inhibitor sc-560 (1 μM), or the COX-2 inhibitor NS398 (10 μM) for 5 min, then incubated with 10 μM AA for 1 min at 23 °C. The reaction mixture after incubation was employed PGE2 EIA (a). Dose-dependent inhibition of WWL70 was examined to determine its IC50 on PGE2 synthesis (b). Data are presented as mean ± SD (n = 3–6). Triple asterisks denote p < 0.001, respectively

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