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Table 2 Serum and CSF parameters in HC, IgGOB−, and IgGOB+ patients

From: BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

  HC IgGOB− IgGOB+
Gender (F/M) 13/4 9/5 17/9
Age at LP (years) 43.2 ± 9.2 37.2 ± 10.7 38.2 ± 9.7
Disease duration (years) n.a. 0.3 ± 0.6 0.6 ± 1.1
Csf-[Alb] (mg/dL) 17.0 ± 5.1 21.2 ± 8.7 23.1 ± 10.4
S-[Alb] (mg/dL) 4370.6 ± 379.0 4225.0 ± 297.7 4278.8 ± 355.6
QAlb (10−3) 3.9 ± 1.2 5.0 ± 2.0 5.4 ± 2.4*
Csf-[IgG] (mg/dL) 2.2 ± 0.9 2.4 ± 0.8 4.5 ± 1.8**** °°°°
S-[IgG] (mg/dL) 1141.2 ± 215.2 944.6 ± 124.2** 1094.3 ± 211.6°
QIgG (10−3) 1.9 ± 0.6 2.6 ± 1.0 4.2 ± 1.8**** °°
IgG Index 0.5 ± 0.1 0.5 ± 0.1 0.8 ± 0.3**** °°°
IgG Loc (mg/dL) 0.1 ± 0.3 0.2 ± 0.6 9.0 ± 11.5** °
IgIF (%) 0 ± 0 1.1 ± 2.7 16.4 ± 18.5*** °°
Leukocyte counts (/μL) 2.1 ± 1.1 2.9 ± 2.4 9.0 ± 8.6*** °
Csf -[BAFF] (pg/mL) 67.3 ± 21.6 69.9 ± 27.3 50.7 ± 20.5* °
BAFF Index 17.5 ± 5.2 13.2 ± 5.1 11.9 ± 6.1**
Csf-[CXCL13] (pg/mL) 0.9 ± 1.5 5.0 ± 8.2 27.7 ± 33.5*** °
Csf-[IL21] (pg/mL) 28.1 ± 29.1 21.6 ± 25.3 20.2 ± 21.9
  1. IgGOB+ patients differed from both BOIgG− and HC for intrathecal IgG synthesis parameters, CSF CXCL13 concentrations, and BAFF Index values. For gender, IgIF%, and IgGOB, chi square test was applied. For all the other variables, a t test was performed. Abbreviations as in Table 1
  2. P values compared to HC: *p < 0.5; **p < 0.01; ***p < 0.005; ****p < 0.001; p values compared to IgGOB−: °p < 0.5; °°p < 0.01; °°°p < 0.005; °°°°p < 0.001