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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype

Fig. 7

Possible mechanism of PD-1/PD-L1 in secondary brain injury after ICH modeling. After ICH, PD-1/PD-L1 protein expression in the brain tissue significantly increased. In addition, the proportion of STAT1 phosphorylation increased. Moreover, upregulation of PD-1/PD-L1 expression by overexpression suppressed the phosphorylation of p-STAT1, pro-inflammatory polarization of microglia, and subsequent SBI under ICH condition, while PD-1/PD-L1 knockdown induced an opposite effect

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Journal of Neuroinflammation

ISSN: 1742-2094