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Table 1 Demographical characteristics and neuropsychiatric tests in the interleukin-1 beta C-carrier and TT-carriers in 135 cases

From: Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Group C-carrier
(n = 108)
TT-carriers
(n = 27)
p value
Age 71.7(14.2) 72.6(7.4) 0.77
Education (year) 6.9(4.7) 9.3(4.8) 0.02
Apolipoprotein E4 carrier (positive case, %) 42.6% 48.1% 0.67
Sex (male/female) 56/52 14/13 1
Mini-Mental State Examination 20.2(6.2) 20.6(7.7) 0.82
CASI total scores 67.8(20.2) 68.3(25.1) 0.89
CASI executive function test scores 25.3(7.9) 25.2(10.1) 0.97
CASI subdomains
 Short term memory 5.5(3.8) 5.4(3.8) 0.90
 Orientation 12.8(5.1) 12.9(6.0) 0.88
 Long term memory 8.3(2.4) 8.4(2.7) 0.90
 Language 8.2(2.1) 8.1(2.8) 0.83
 Drawing 7.8(2.8) 8.4(2.6) 0.37
 Attention 6.3(1.4) 6.3(1.6) 0.98
 Verbal fluency 5.2(2.5) 5.3(3.7) 0.86
 Abstract thinking 8.2(2.8) 7.9(3.2) 0.64
 Mental manipulation 5.6(3.2) 5.7(3.4) 0.92
Cerebrovascular risk biomarkers
 High sensitive C reactive protein (mg/L) 2.8(4.9) 2.4(5.2) 0.68
 Homocysteine (umol/L) 12.9(4.3) 11.5(4.7) 0.14
 Hemoglobin-A1C (%) 6.1(1.0) 6.2(1.7) 0.74
 Creatinine (mg/dl) 0.9(0.4) 0.9(0.2) 0.52
 High-density lipoprotein (mg/dl) 57.1(17.0) 61.0(16.6) 0.29
 Low-density lipoprotein (mg/dl) 106.2(38.1) 97.4(28.6) 0.27
 Total cholesterol (mg/dl) 188.5(40.8) 180.6(36.0) 0.36
 Triglyceride (mg/dl) 120.7(62.0) 110.7(55.0) 0.44
 Vitamin B12 (pg/dl) 589.1 (315.7) 687.2(428.1) 0.19
 Folate (ng/dl) 12.0(5.6) 12.8(5.4) 0.52
  1. Data are presented as mean (standard deviation) or number (percentage (%))
  2. Attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI were added to assess executive function
  3. APOE4 carriers were defined as the presence of one or two APOE4 alleles
  4. CASI Cognitive Ability Screening Instrument