Skip to main content

Table 3 Connectivity interactions of interleukin-1 beta genotypes with pre-defined seed

From: Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Seed Peak regions   Stereotaxic coordinates Extent MaxT p value
    x y z    
C-carrier > TT
 Entorhinal seed Middle cingulum R 5 −12 48 118 3.81 0.0001
 PCC seed N.A        
 Frontoinsular seed N.A        
 Dorsolateral prefrontal N.A        
C-carrier < TT
 Entorhinal seed N.A        
 PCC seed N.A        
 Frontoinsular seed BA 10 R 19.5 63 3.0 196 4.51 0.0001
Middle frontal R 31.5 10.5 58.5 243 3.47 0.0001
 Dorsolateral prefrontal Superior frontal R 21 37.5 49.5 671 5.09 0.0001
Precentral L −52.5 −1.5 −43.5 214 3.58 0.0001
Fusiform L −43.5 −54 −15 123 4.17 0.0001
Inferior temporal R 40.5 −55.5 −9 119 4.03 0.0001
  1. Peak regions are within the main cluster
  2. Max T is the maximum T statistic for each local maximum. p < 0.001 with cluster size = 100
  3. N.A not available, PCC Posterior cingulate cortex, BA Brodmann area, R right, L left