Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Table 3 Connectivity interactions of interleukin-1 beta genotypes with pre-defined seed

Seed	Peak regions		Stereotaxic coordinates			Extent	MaxT	p value
			x	y	z
C-carrier > TT
Entorhinal seed	Middle cingulum	R	5	−12	48	118	3.81	0.0001
PCC seed	N.A
Frontoinsular seed	N.A
Dorsolateral prefrontal	N.A
C-carrier < TT
Entorhinal seed	N.A
PCC seed	N.A
Frontoinsular seed	BA 10	R	19.5	63	3.0	196	4.51	0.0001
Frontoinsular seed	Middle frontal	R	31.5	10.5	58.5	243	3.47	0.0001
Dorsolateral prefrontal	Superior frontal	R	21	37.5	49.5	671	5.09	0.0001
	Precentral	L	−52.5	−1.5	−43.5	214	3.58	0.0001
	Fusiform	L	−43.5	−54	−15	123	4.17	0.0001
	Inferior temporal	R	40.5	−55.5	−9	119	4.03	0.0001

Peak regions are within the main cluster
Max T is the maximum T statistic for each local maximum. p < 0.001 with cluster size = 100
N.A not available, PCC Posterior cingulate cortex, BA Brodmann area, R right, L left

ISSN: 1742-2094