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Table 4 Correlation matrix between cognitive test scores with peak clusters volume

From: Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Covariance strength relationship C > TT C < TT
Seed region R entorhinal R frontoinsular seed R dorsolateral seed
Peak clusters R cingulum BA10 BA6 R superior sagittal
prefrontal
L precentral L fusiform gyrus R temporal
Cognitive tests IL-1 beta genotype :-511 C-carriers
MMSE 0.24* 0.07 0.15 0.16 0.24* 0.17 0.06
CASI total scores 0.26** 0.09 0.19* 0.17 0.28** 0.19 0.05
CASI EFT scores 0.21* 0.12 0.16 0.13 0.25** 0.19* 0.07
CASI subdomains
 Short-term memory 0.21* 0.04 0.08 0.12 0.26** 0.07 0.05
 Orientation 0.22* −0.03 0.15 0.09 0.24* 0.16 0.08
 Long-term memory 0.31** 0.05 0.16 0.18 0.25** 0.04 0.15
 Language 0.16 0.04 0.16 0.30** 0.25 0.09 −0.06
 Drawing 0.14 0.16 0.19 0.11 0.05 0.29** −0.06
 Attention 0.17 0.05 0.17 0.06 0.30** 0.01 −0.07
 Verbal fluency 0.23* 0.04 0.04 0.18 0.23* 0.18 0.03
 Abstract thinking 0.20* 0.11 0.12 0.09 0.12 0.25* 0.07
 Mental manipulation 0.07 0.14 0.14 0.12 0.17 0.17 0.15
Cognitive tests IL-1 beta genotype :-511 TT
MMSE 0.12 0.43* 0.39* 0.36 0.30 0.40* 0.48*
CASI total scores 0.14 0.47* 0.44* 0.48* 0.34 0.35 0.56**
CASI EFT scores 0.21 0.44* 0.39* 0.39* 0.40* 0.35 0.60**
CASI Subdomains
 Short Term Memory −0.03 0.34 0.19 0.38 0.02 0.37 0.22
 Orientation 0.16 0.43* 0.39 0.42* 0.24 0.30 0.46*
 Long Term Memory 0.02 0.36 0.49 0.54** 0.39* 0.22 0.56**
 Language 0.11 0.38 0.51 0.48* 0.43* 0.30 0.60**
 Drawing 0.09 0.55** 0.48 0.54** 0.31 0.26 0.51**
 Attention 0.06 0.32 0.27 0.35 0.39 0.33 0.57**
 Verbal fluency 0.30 0.69** 0.46* 0.27 0.29 0.23 0.39*
 Abstract thinking 0.26 0.37 0.40* 0.39 0.41* 0.19 0.56**
 Mental manipulation 0.01 0.29 0.30 0.29 0.28 0.43* 0.47*
  1. Numbers indicate Pearson correlation coefficients between peak cluster volume and test scores, *p < 0.05; **p < 0.01
  2. MMSE Mini-Mental State Examination, EFT executive function test, R right, L left, IL-1 interleukin-1, CASI Cognitive Abilities Screening Instrument, BA Brodmann area, C IL-1 beta C-carrier, TT T Homozygotes