Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Table 4 Correlation matrix between cognitive test scores with peak clusters volume

Covariance strength relationship	C > TT	C < TT
Seed region	R entorhinal	R frontoinsular seed		R dorsolateral seed
Peak clusters	R cingulum	BA10	BA6	R superior sagittal prefrontal	L precentral	L fusiform gyrus	R temporal
Cognitive tests	IL-1 beta genotype :-511 C-carriers
MMSE	0.24*	0.07	0.15	0.16	0.24*	0.17	0.06
CASI total scores	0.26**	0.09	0.19*	0.17	0.28**	0.19	0.05
CASI EFT scores	0.21*	0.12	0.16	0.13	0.25**	0.19*	0.07
CASI subdomains
Short-term memory	0.21*	0.04	0.08	0.12	0.26**	0.07	0.05
Orientation	0.22*	−0.03	0.15	0.09	0.24*	0.16	0.08
Long-term memory	0.31**	0.05	0.16	0.18	0.25**	0.04	0.15
Language	0.16	0.04	0.16	0.30**	0.25	0.09	−0.06
Drawing	0.14	0.16	0.19	0.11	0.05	0.29**	−0.06
Attention	0.17	0.05	0.17	0.06	0.30**	0.01	−0.07
Verbal fluency	0.23*	0.04	0.04	0.18	0.23*	0.18	0.03
Abstract thinking	0.20*	0.11	0.12	0.09	0.12	0.25*	0.07
Mental manipulation	0.07	0.14	0.14	0.12	0.17	0.17	0.15
Cognitive tests	IL-1 beta genotype :-511 TT
MMSE	0.12	0.43*	0.39*	0.36	0.30	0.40*	0.48*
CASI total scores	0.14	0.47*	0.44*	0.48*	0.34	0.35	0.56**
CASI EFT scores	0.21	0.44*	0.39*	0.39*	0.40*	0.35	0.60**
CASI Subdomains
Short Term Memory	−0.03	0.34	0.19	0.38	0.02	0.37	0.22
Orientation	0.16	0.43*	0.39	0.42*	0.24	0.30	0.46*
Long Term Memory	0.02	0.36	0.49	0.54**	0.39*	0.22	0.56**
Language	0.11	0.38	0.51	0.48*	0.43*	0.30	0.60**
Drawing	0.09	0.55**	0.48	0.54**	0.31	0.26	0.51**
Attention	0.06	0.32	0.27	0.35	0.39	0.33	0.57**
Verbal fluency	0.30	0.69**	0.46*	0.27	0.29	0.23	0.39*
Abstract thinking	0.26	0.37	0.40*	0.39	0.41*	0.19	0.56**
Mental manipulation	0.01	0.29	0.30	0.29	0.28	0.43*	0.47*

Numbers indicate Pearson correlation coefficients between peak cluster volume and test scores, *p < 0.05; **p < 0.01
MMSE Mini-Mental State Examination, EFT executive function test, R right, L left, IL-1 interleukin-1, CASI Cognitive Abilities Screening Instrument, BA Brodmann area, C IL-1 beta C-carrier, TT T Homozygotes

ISSN: 1742-2094