Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid

Fig. 3

Effect of different concentrations of QA and rapamycin on the glutamate release in striatal synaptosomes. a Synaptosomes were incubated with different concentration of QA (0.1, 0.5, 5, and 10 mM) (n = 2–3). b Previously, synaptosomes were incubated with rapamycin (10−4, 10−3, 0.05, or 0.25 nM) for 15 min, and after, QA 5 mM were added. The glutamate release was evaluated by continuous fluorometric assay. Results are expressed as mean ± SEM (n = 3–10 independent experiments/group). **p < 0.05, ***p < 0.01 as compared with KCl 33 mM. ### p < 0.001, ## p < 0.01, and # p < 0.05 as compared with QA 5 mM (one-way ANOVA followed by Newman-Keuls test)

Back to article page