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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis

Fig. 2

HIV activates the C3 promoter inducing transcription and protein production by HFA. HFA were exposed to NL4-3 at 0.5, 1.0, and 2.5 pg per cell or mock-infected and samples collected to measure C3 products. a Activation of C3 promoter directed luciferase production was measured 2 days after virus exposure; data are expressed as relative light units (RLU). b C3 mRNA was measured by QPCR 1 week after virus exposure. c Extracellular C3 protein was measured by ELISA 1 week after virus exposure. The differences in values between mock-infected and the other groups were tested by one-way ANOVA and Dunnett’s post hoc analysis with asterisk indicating p < 0.05. Statistical values are provided in Additional file 1: Table S1

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