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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis

Fig. 8

HIV activates the IL-6 promoter through NF-κB. a HFA transfected with the IL-6 promoter driving luciferase were exposed to HIV at 0.5 or 2.5 pg p24 per cell in the presence or absence of CAPE. Luciferase activity was measured and the difference in values between mock-infected and the other experimental groups a. Luciferase activity was measured for HFA transfected with the IL-6 promoter driving luciferase were exposed to HIV at 0.5 or 2.5 pg per cell or mock virus in the presence or absence of CAPE a and IL-6 promoter and a mutant in the κB site b. The differences in values between mock-infected and HIV-infected cells were tested by a one-way ANOVA and Dunnett’s post hoc analysis with asterisk indicating p < 0.05 and by Student’s t test with asterisk indicating p < 0.05 and b number sign for NF-κB mutant vs. wild type. Statistical values are provided in the Additional file 1: Table S1

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