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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures

Fig. 3

Decreased ERK phosphorylation by everolimus, minocyclin, and rapamycin under both LPS and kainic acid treatment in BV2 cell line. a After both LPS and kainic acid (KA) treatment for 24 h, ERK phosphorylation was attenuated significantly by everolimus (LE and KE groups), minocycline (LM and KM groups), and rapamycin (LR and KR groups), while everolimus performed best. b, c No effect on Akt and mTOR phosphorylation by everolimus, minocycline, and rapamycin was noted. n = 5 for each group. ***p < 0.001; **p < 0.01;*p < 0.05, compared with the control group (Ctl). ## p < 0.01; # p < 0.05, compared with the LPS and KA groups. Data are presented as mean ± SEM. Ctl control, Eve/E everolimus, KA/K kainic acid, LPS/L lipopolysaccharide, Min/M minocycline, Rap/R rapamycin

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