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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures

Fig. 5

Decreased ERK phosphorylation by everolimus significantly in the animal model of kainic acid-induced seizures. B6.129P-Cx3cr1tm1Litt/J mice received kainic acid (KA) i.p. injection on day 1 and day 7 (two-hit seizure model), and received i.p. injection of PBS (KpK group) or everolimus (KeK group) during day 1 to day 6. Sham mice received PBS during day 1 to day 7 (PpP group). Twenty-four hours after KA injection on day 7, mice were sacrificed, the hippocampus was resected, and the protein expression was analyzed by Western blotting. a KA injection twice significantly increased ERK phosphorylation, which was attenuated by everolimus. b, c Everolimus did not decrease Akt and mTOR phosphorylation after repeated KA injection. Bars depict mean ± S.E.M. The number of mice used in each experiment was shown in the bottom of each bar figure. *p = 0.034 and **p = 0.004, compared with the sham group; m: p = 0.048, compared between KeK and KpK groups

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