Fig. 8From: Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7Proposed mechanism of HMGB1 and let-7 release in microvesicles. Ethanol causes an increase in TLR7 expression, and release of let-7b and HMGB1 from microglia in microvesicles, potentiating neurodegeneration. Ethanol increases the binding of let-7 with HMGB1 in microvesicles. HMGB1 inhibition with glycyrrhizin prevented TLR7 mediated neurotoxicityBack to article page