Fig. 6
From: Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis
Anti-TNFα suppresses neutrophil MMP-9 secretion, but dexamethasone does not. a MMP-9 secretion is inhibited by anti-TNFα pre-treatment of neutrophils. CoMTB was incubated with anti-TNFα antibodies for 1 h before neutrophil stimulation. b Anti-TNFα inhibits MMP-9 gene expression. c TIMP-1 secretion is not affected by anti-TNFα. d TIMP-2 secretion is reduced by anti-TNFα. e MMP-9 secretion is not affected by dexamethasone. f Dexamethasone inhibits neutrophil MMP-8 secretion. Bars represent mean ± s.d and are representative of at least two independent experiments performed in triplicate. *P < 0.05; **P < 0.01; ***P < 0.001